Professor Ennis is interested in both the basic science and clinical applications of MRI for evaluating cardiovascular structure, function, and remodeling. Work in his laboratory uses a principled combination of theory, simulation, and experimental work to bring improvements to the imaging speed and accuracy of cardiovascular MRI exams. In particular, his group is currently focused on developing advanced methods for pediatric cardiovascular exams that may improve patient acceptance, while maintaining or improving diagnostic image quality. His group is also focused on developing quantitative imaging methods that can provide insight to changes in cardiovascular structure and function during the progression of disease or in response to pharmacologic therapy.
Scientists in his group also work to better understand the risks associated with MRI scanning of patients with implanted devices and technical approaches to mitigating these risks by modifying the MRI exam.
Researchers in the Ennis Lab are also developing methods that provide insight to myocardial microstructural remodeling in disease by evaluating changes microstructural organization that can be measured with DT-MRI and evaluated with tensor-field image processing methods. These same studies lend themselves to the building of computational models of cardiac electrophysiology, which can be used to better understand electrical abnormalities of the heart.